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In vivo molecular determinants of progression and therapeutic resistance in prostate cancer
Gastroenterology; ion transport in epithelia, membrane physiology, cellular ion transportreflux.
HIV pathogenesis: neoplastic growth control; gene therapy; mechanisms of drug-induced toxicities
Hematopoiesis; clinical and experimental bone marrow transplantation
AIDS neuropathogenesis, immunology
Reproductive toxicology; heavy metal toxicity in placental function
Inherited metabolic diseases
HIV/SIV diversity and pathogenesis
Viral hemorrhagic fevers and emerging viruses
Cellular/molecular pharmacology; signal transduction, hematopoietic growth factors, and cancer.
Pathogenesis of retrovirally-induced central nervous system diseases, HTLV-I/II invections, retroviral co-infections
Molecular dynamics simulations; structure and dynamics of DNA; free energy studies of ligand receptor interactions
Effects of extracellular matrix on cell growth and wound healing; isolation and characterization of anti-metal antibodies
Schistosomes & other helminth parasites; molecular, genomic & biochemical studies
Gene transfer/therapy, stem cells (mesenchymal and hematopoietic), lysosomal storage diseases, animal models and vector development.
Estrogen receptor-mediated cell signaling, gene expression regulation and cell survival, tumor progression and drug resistant phenotype.
- Host-parasite interactions in fungal and bacterial infections
- Molecular Virology
- Molecular mechanisms of AIDS pathogenesis and angiogenesis
Cardiac electrophysiology; molecular biology of ion channels; effects of antiarrhythmic drugs on ion channels; regulation of ion channel expression; cardiotoxicity of local anesthetics.
- Bacterial Pathogenesis
- Molecular aspects of the host-parasite relationship
- Vaccine Development
Neural mechanisms of memory formation; age-related decline of memory and cognition
Nutrition therapy in patients with heritable metabolic disease
Molecular studies of hepatitis C virus replication, mechanisms of interferon against hep. C and development of smaller size humanized recombinant antibodies to treat hep. C infection
We are interested in how human mobile elements contribute an intrinsic instability to the human genome. This is particularly relevant to the causation of cancer. We are exploring the variations in these elements between different individuals to determine
General Cardiology, interventional cardiology, hypertension and vascular biology
Dr. DeSalvo’s research interests include developing strategies to identifying high risk patients with chronic disease and developing patient-centered care delivery systems for them.
Immunology; pathogenesis; drug discovery for microsporidiosis in murine and non-human primate models
Endocrine influences on learning and memory
Androgen receptor signaling in selenium chemoprevention of prostate cancer, selenium sensitization of chemotherapy or hormonal therapy in relation to breast cancer, as well as prostate and breast cancer intervention with ginsenosides, a class of steroid-l
Aberrant DNA methylation and chromatin structure in cancer and inherited syndromes; effects on chromosome stability and gene expression
Transcriptional control of kidney development
Cell-cycle regulation, transcriptional regulation, development of siRNA technology for therapeutics and discovery
Cerebral morphometry and morphological asymmetries in humans, neurobehavioral syndromes in man with emphasis on aphasia, apraxia, and amnesia.
The role of MEN1 and RET gene products in cell cycle regulation
- Bacterial Pathogenesis
- Molecular Vaccine Development
- Virology
- Molecular mechanisms of viral pathogenesis
Adult stem cells, osteogenesis, cancers of bone
Cellular and molecular mechanisms of epithelial transport of sodium and acid-base
Medical Transplant Management (Kidney and Kidney-Pancreas) Research, Proximal Tubule Protein Handling, Space Medicine
Molecular biology of acute leukemias
Dr. Hering-Smith has extensive experience in studies of sodium transport and acid-base transport including that of citrate; these studies have primarily utilized isolated perfused tubules, cell culture, and a variety of cell and molecular techniques.
Endocrine response mechanisms of breast cancer, in particular steroid hormone receptors; neuroendocrine influences on breast cancer.
Computational chemistry
Transgenic mouse models of lung disease
- Microscopy
Integrative Cardiovascular and Renal Physiology
Immunity and immunopathogenesis in malaria
Control of cellular differentiation; role of protein phosphorylation and the oncongene c-fos and c-myc in the control of differentiation and proliferation in Friend erythroleukemia cells.
Cardiovascular gene therapy
Phage genomics; RNA-binding proteins; DNA replication
Tubular renin-angiotensin system
Neurophysiology
Mechanisms and genetic bases of anti-malarial resistance; molecular analysis of clonality in natural infection
Pathogenesis of infectious diseases, immunology, AIDS and neurovirology
Protein folding and protein-protein interactions; molecular chaperone proteins; antigen processing
Stromal cell-stem cell interactions in bone marrow
Investigation into the pathogenesis of fibrotic lung disease
- Molecular Virology
- Molecular mechanisms of retroviral oncogenesis
Pharmacology of Ion channels, T-type Ca Channels, Cellular Electrophysiology, Pancreatic Islet cells.
Glycobiology – Biochemical basis of inborn lysosomal diseases and biomedically useful glycosidases
Glycobiology – Biochemical basis of inborn lysosomal diseases and biomedically useful glycosidases
Role of telomere dynamics in chromosome stability and transcriptional regulation
Renal hemodynamics and excretory function: regulation by endothelial factors
ICharacterizing genetic elements that affect cancer risk or progression in the androgen metabolic and DNA repair pathways , measuring the rate of genomic instability in cancer tissue
Simian Models of AIDS and SIV Origins of HIV
Developmental biology and toxicology of estrogen and estrogenic environmental chemicals, gene imprinting in development
Responses of the vascular wall to injury; intimal hyperplasia; restenosis; nitric oxide, arachidonic acid, and prostaglandin metabolism.
Molecular toxicology, yeast genetics, transcription, replication, and repair of DNA
Renal Physiology; Renin-Angiotensin System
Molecular mechanisms linked to HIV-1 induced pathogenesis, role of HIV-1 transactivator protein in regulating viral latency and infectivity. Possible pharmacological interventions to enhance the efficacy & reduce the side effects of anti-retroviral drugs.
- Bacterial Pathogenesis
- Studies of host-pathogen relationship during pulmonary infection
- Vaccine discovery and development against aerosol bacterial agents
Molecular biology of the lung and transcriptional regulation of the proliferating cell nuclear antigen
Cellular and molecular mechanisms of transporters involved in acid-base transport and regulation of intracellular pH
Clinical Genetics
Renal Microcirculation, Renin-Angiotensin System, Experimental Hypertension, Renal Hemodynamics
Cell and tissue engineering, biocomputation, oncology, and stem cell technology
ANP receptor gene: targeting and expression
SIV/HIV Pathogenesis and Diversity
Membrane proteins and lipoproteins of Borrelia burgdorferi, the spirochete that causes Lyme disease.Pathogenesis and diagnosis of Lyme disease
Molecular characterization of mesynchymal stem cells and their use as cellular vectors in gene therapy
Characterization of primitive progenitor/stem cells from bone marrow stroma and cancer stem cells of osteosarcoma
Genetics of preclampsia, maternal PKU, hurricane effects upon pregnancy
Experimental High blood pressure; gene expression and regulation of intrarenal renin angiotensin system
Gene therapy using stem cells
Macromolecular biophysics; polymer physics; light scattering, equilibrium and non-equilibrium macromolecular characterization
Development of monoclonal antibodies directed against the HIV virus
Molecular Mechanisms of Steroid Receptors in Hormone-Dependent Cancer
- Proliferative pathways in renal organogenesis
- Molecular and Cellular Biology
- Oxygen-sensing Genetic Mechanisms
- Post-transcriptional Control of Oxygen Regulated Genes
- RNA Binding Proteins
- Angiogenesis and Cancer Research
Pathogenesis of gastrointestinal diseases; mucosal immunity
The Role of Histone Deacetylase in Lung Cancer Metastasis and Idiopathic Pulmonary Fibrosis.
Free redical/oxidative stress induced molecular and cellular mechanisms and interactions related to male reproductive toxicology, sexual dysfunction, and prostate tumorigenesis
- Molecular mechanisms of pulmonary fibrogenesis
The neurobiological basis of pain and analgesia
Molecular mechanisms of viral pathogenesis and carcinogenesis
- Cell - virus interactions and the role of Pathogenesis of acute viral infections
- Therapeutic and vaccine development
Functional and structural organization of retinal ganglion cells in developing and mature retina.
Genetic epidemiology, psychiatric genetics
Medical/molecular entomology; ecology of arbovirus vectors; molecular phylogenetics and systematics of medically important arthropods
Fundamental principles of the folding and structure of peptides and proteins in membranes
Molecular and cellular biology of protozoan parasites; host-parasite interactions
Elucidation of the role of the renin-angiotensin system in branching morphogenesis of the ureteric bud and kidney development
Peptides, especially opioids; receptor binding, mechanisms of action, behavioral and developmental effects.
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